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    Home » Glossário » Z » What is: Zafirlukast (asthma medication)

    What is: Zafirlukast (asthma medication)

    By September 28, 20243 Mins Read
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    What is Zafirlukast?

    Zafirlukast is a medication primarily used to manage asthma symptoms and prevent asthma attacks. It belongs to a class of drugs known as leukotriene receptor antagonists (LTRAs), which work by blocking the action of leukotrienes—substances in the body that cause inflammation, bronchoconstriction, and mucus production in the airways. By inhibiting these substances, Zafirlukast helps to reduce airway inflammation and improve breathing in individuals with asthma.

    How Does Zafirlukast Work?

    The mechanism of action of Zafirlukast involves the selective inhibition of leukotriene receptors, specifically the CysLT1 receptor. By blocking these receptors, Zafirlukast prevents leukotrienes from binding and exerting their effects, which include bronchial smooth muscle contraction and increased vascular permeability. This action leads to decreased inflammation and swelling in the airways, making it easier for patients to breathe and reducing the frequency of asthma attacks.

    Indications for Use

    Zafirlukast is indicated for the prophylaxis and chronic treatment of asthma in adults and children aged 5 years and older. It is particularly beneficial for patients who experience exercise-induced bronchoconstriction or those who have not achieved adequate control of their asthma symptoms with inhaled corticosteroids alone. Zafirlukast can be used as an adjunct therapy alongside other asthma medications, such as bronchodilators and corticosteroids.

    Dosage and Administration

    The typical dosage of Zafirlukast for adults is 20 mg taken twice daily, while children aged 5 to 11 years are usually prescribed 10 mg twice daily. It is essential to take Zafirlukast on an empty stomach, at least one hour before or two hours after meals, to ensure optimal absorption. Patients should follow their healthcare provider's instructions regarding dosage adjustments and adherence to the prescribed regimen for effective asthma management.

    Potential Side Effects

    Like any medication, Zafirlukast may cause side effects, although not everyone will experience them. Common side effects include headache, dizziness, abdominal pain, and nausea. In rare cases, more severe side effects such as liver enzyme elevations, hypersensitivity reactions, or mood changes may occur. Patients should be advised to report any unusual symptoms or side effects to their healthcare provider promptly.

    Drug Interactions

    Zafirlukast may interact with other medications, potentially affecting its efficacy or increasing the risk of side effects. Notably, it can interact with warfarin, leading to altered anticoagulant effects. Additionally, the use of Zafirlukast with certain medications that are metabolized by the liver may require careful monitoring. It is crucial for patients to inform their healthcare provider about all medications, supplements, and herbal products they are taking to avoid potential interactions.

    Precautions and Contraindications

    Before starting Zafirlukast, patients should inform their healthcare provider of any existing medical conditions, particularly liver disease, as this may affect the drug's metabolism. Zafirlukast is contraindicated in individuals with a known hypersensitivity to the drug or any of its components. Pregnant or breastfeeding women should discuss the risks and benefits of using Zafirlukast with their healthcare provider to ensure the safety of both mother and child.

    Monitoring and Follow-Up

    Patients using Zafirlukast should have regular follow-up appointments with their healthcare provider to monitor their asthma control and assess the effectiveness of the medication. Healthcare providers may recommend periodic liver function tests, especially for patients with pre-existing liver conditions. It is essential for patients to keep track of their asthma symptoms and any changes in their condition to facilitate timely adjustments to their treatment plan.

    Conclusion

    Zafirlukast is a valuable medication for asthma management, offering patients an alternative to traditional inhaled therapies. By understanding its mechanism of action, indications, and potential side effects, patients can work closely with their healthcare providers to optimize their asthma treatment and improve their quality of life.

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